题 目：MOLECULARLYIMPRINTEDNANOPARTICLES (MINPS) AS HIGHLYSELECTIVEARTIFICIALRECEPTORS ANDENZYMES

报告人：Zhao Yan　教授

单 位：Iowa State University

时 间：2025/6/10　10:00

地 点：嘉锡楼三层305报告厅

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附简介：

Creation of synthetic receptors to bind biologically important molecules in water with high affinity and specificity is challenging,but can be achieved through molecular imprinting within cross-linkable surfactant micelles. The resulting molecularly imprinted nanoparticles (MINPs) are characterized by their discrete binding sites and great resemblance to protein receptors in their nanodimension,water-solubility,a functionalizable exterior,and easily accessible,tailor-made hydrophobic binding pockets. MINPs could be made to recognize peptides by their amino acid sequence,side chains,and chain length. They distinguish monosaccharides by their number and orientation of hydroxyls and oligosaccharides by their sugar building blocks,α/β glycosidic linkage,and chain length. When installed with catalytic functionalities,they perform highly selective chemical transformations as synthetic enzymes,including efficient hydrolysis of oligo- and polysaccharides,hydrolysis of ester at room temperature and pH 7,site-selective functionalization of biomolecules,and asymmetric catalysis.

Biography: Yan Zhao received his B.S. in chemistry from Lanzhou University in 1992 and Ph.D. from Northwestern University in 1996. After a postdoctoral stay at the University of Illinois,he worked for the Procter & Gamble Company from 1998 to 2002. He is currently a professor of chemistry at Iowa State University and an elected Fellow of the American Association for the Advancement of Science (AAAS).

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报告网页链接如下：Zhao Yan教授学术报告链接